{"product_id":"iκb-alpha-polyclonal-antibody-bt-ap10545","title":"IκB-alpha Polyclonal Antibody - BT-AP10545","description":"\u003cp\u003eIκB-alpha Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10545-20, BT-AP10545-50, BT-AP10545-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B\/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Epigenetics and nuclear signaling; Immunology; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: NFKBIA\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: NF-kappa-B inhibitor alpha\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P25963; Mouse: Q9Z1E3; Rat: Q63746\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: NF-kappa-B inhibitor alpha; NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4792\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239186686131,"sku":"BT-AP10545-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239186718899,"sku":"BT-AP10545-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239186751667,"sku":"BT-AP10545-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5c49a0f0-0b24-4584-971f-fb5aeafe10a2.png?v=1769390293","url":"https:\/\/afsbio.com\/products\/i%ce%bab-alpha-polyclonal-antibody-bt-ap10545","provider":"AFSBio Inc.","version":"1.0","type":"link"}