{"product_id":"i12r2-polyclonal-antibody-bt-ap10253","title":"I12R2 Polyclonal Antibody - BT-AP10253","description":"\u003cp\u003eI12R2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10253-20, BT-AP10253-50, BT-AP10253-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohnandapos;s disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: IL12RB2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Interleukin-12 receptor subunit beta-2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q99665; Mouse: P97378\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Interleukin-12 receptor subunit beta-2;IL-12 receptor subunit beta-2;IL-12R subunit beta-2;IL-12R-beta-2;IL-12RB2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 3595\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239175217331,"sku":"BT-AP10253-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239175250099,"sku":"BT-AP10253-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239175282867,"sku":"BT-AP10253-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_03be7c62-7fb8-4885-a8f4-68319d400798.png?v=1769390166","url":"https:\/\/afsbio.com\/products\/i12r2-polyclonal-antibody-bt-ap10253","provider":"AFSBio Inc.","version":"1.0","type":"link"}