{"product_id":"i23o1-polyclonal-antibody-bt-ap10258","title":"I23O1 Polyclonal Antibody - BT-AP10258","description":"\u003cp\u003eI23O1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10258-20, BT-AP10258-50, BT-AP10258-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular; Signal transduction; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: IDO1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Indoleamine 2,3-dioxygenase 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P14902; Mouse: P28776; Rat: Q9ERD9\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Indoleamine 2,3-dioxygenase 1;IDO-1;EC 1.13.11.52;Indoleamine-pyrrole 2,3-dioxygenase\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 3620\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239175905459,"sku":"BT-AP10258-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239175938227,"sku":"BT-AP10258-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239175970995,"sku":"BT-AP10258-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f6229abb-c79b-48b0-abce-460b6af51a24.png?v=1769390173","url":"https:\/\/afsbio.com\/products\/i23o1-polyclonal-antibody-bt-ap10258","provider":"AFSBio Inc.","version":"1.0","type":"link"}