{"product_id":"ibtk-polyclonal-antibody-bt-ap10264","title":"IBTK Polyclonal Antibody - BT-AP10264","description":"\u003cp\u003eIBTK Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10264-20, BT-AP10264-50, BT-AP10264-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTKandapos;s kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Immunology; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: IBTK\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Inhibitor of Bruton tyrosine kinase\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9P2D0; Mouse: Q6ZPR6\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Inhibitor of Bruton tyrosine kinase;IBtk\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 25998\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239176396979,"sku":"BT-AP10264-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239176429747,"sku":"BT-AP10264-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239176462515,"sku":"BT-AP10264-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d253de99-7653-40d3-b50b-9cb1f859471e.png?v=1769390180","url":"https:\/\/afsbio.com\/products\/ibtk-polyclonal-antibody-bt-ap10264","provider":"AFSBio Inc.","version":"1.0","type":"link"}