{"product_id":"ide-monoclonal-antibody-mb65959","title":"IDE Monoclonal Antibody-MB65959","description":"\u003cp\u003eIDE Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB65959-50, MB65959-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P14735\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/1000 - 1\/2000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Insulin degrading enzyme (IDE), initiates the cleavage of Insulin, resulting in Insulin response and resistance. However, IDE also degrades a variety of bioactive peptides, including Amyloid-β peptides, implicating IDE in certain age-related changes seen in Alzheimer’s disease. Studies show that when the expression of the IDE gene (chromosome 10q23.33) is altered, changes occur not only in glucose homeostasis, but also in the levels of brain Aβ40 and Aβ42 peptides. An IDE inhibitor, bacitracin, inhibits degradation of both Insulin and amylin, indicating that both are degraded through a common proteolytic pathway. Variations in the rate of proteolysis suggest that the function of IDE exhibits conformational dependence, which may lead to possible therapeutic interventions for diabetes, AD, and other diseases associated\u003cbr\u003e\nwith IDE substrate proteolysis.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of IDE protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of IDE expression in Hela (A), HepG2 (B) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 118 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Insulin-degrading enzyme; Abeta-degrading protease; Insulin protease; Insulinase; Insulysin\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence of human IDE. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908744548531,"sku":"MB65959-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908744581299,"sku":"MB65959-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_caef8735-447e-4653-af1d-8e305fe09781.jpg?v=1703006555","url":"https:\/\/afsbio.com\/products\/ide-monoclonal-antibody-mb65959","provider":"AFSBio Inc.","version":"1.0","type":"link"}