{"product_id":"ifn-r1-l461-polyclonal-antibody-bs1754","title":"IFN-R1 (L461) Polyclonal Antibody-BS1754","description":"\u003cp\u003eIFN-R1 (L461) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1754-50, BS1754-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P17181\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, IF\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: IHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: The type I interferons, IFN-α and IFN-β, are a group of structurally and functionally related proteins that are induced by either viruses or double-stranded RNA and are defined by their ability to confer an antiviral state in cells. IFN-α and IFN-β appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN-γ) binds to a distinct receptor. This distinct receptor, IFN-αR, is only weakly responsive to type I interferons, in contrast to IFN-α\/βR, which binds to and responds effectively to IFN-β and to several of the IFN-α subtypes. IFN-α\/βR is expressed as two alternatively spliced transcripts, designated IFN-α\/βRα (IFN-α\/βR1) and IFN-α\/βRβ (IFN- α\/βR2), both of which are involved in signal transduction and ligand binding.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunohistochemistry (IHC) analyzes of IFN-R1 (L461) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 50 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IFN-R1 (L461) polyclonal antibody detects endogenous levels of Interferon alpha\/beta receptor 1 protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Interferon alpha\/beta receptor 1; IFN-R-1; IFN-alpha\/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1; IFNAR1; IFNAR; IFNR1; IFN R1; IFN-α\/βRα; IFN-α\/βR1; IFN α\/βRα; IFNα\/βR1; IFNα\/β-Rα; IFNα\/β R1;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 410-460 of Human IFN-R1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939269087411,"sku":"BS1754-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939269120179,"sku":"BS1754-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_631973f0-dd81-4378-8f93-472eeafd191f.jpg?v=1704545718","url":"https:\/\/afsbio.com\/products\/ifn-r1-l461-polyclonal-antibody-bs1754","provider":"AFSBio Inc.","version":"1.0","type":"link"}