{"product_id":"igf-1r-phospho-y1161-polyclonal-antibody-bs4097","title":"IGF-1R (phospho-Y1161) Polyclonal Antibody - BS4097","description":"\u003cp\u003eIGF-1R (phospho-Y1161) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4097-50, BS4097-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Insμlin-like growth factor-I receptor (IGF-IR) is an RTK that stimμlates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimμlate the growth of some types of cancer. The IGF-IR cognate ligand insμlin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modμlar phosphotyrosine binding (PTB) domains of insμlin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals.\u003c\/p\u003e \n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Insμlin-like growth factor 1 receptor, Insμlin-like growth factor I receptor, IGF-I receptor, CD221, Insμlin-like growth factor 1 receptor alpha chain, Insμlin-like growth factor 1 receptor beta chain, IGF1R\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human IGF-1R around the phosphorylation site of Tyrosine 1161.\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-IGF-1R (Y1161) polyclonal antibody detects endogenous levels of IGF-1R protein only when phosphorylated at Tyr1161.This antibody may cross-reacts with insμlin receptor protein when phosphorylated at Tyr1185.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 95, 155 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Tumor Angiogenesis, Insμlin \u0026amp;Glucose Signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P08069\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946278445235,"sku":"BS4097-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946278478003,"sku":"BS4097-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/igf-1r-phospho-y1161-polyclonal-antibody-bs4097","provider":"AFSBio Inc.","version":"1.0","type":"link"}