{"product_id":"igf2bp2-polyclonal-antibody-bs67251","title":"IGF2BP2 Polyclonal Antibody-BS67251","description":"\u003cp\u003eIGF2BP2 Polyclonal Antibody\u003c\/p\u003e \n\n\u003cp\u003eCatalogue Numbers: BS67251-50, BS67251-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9Y6M1\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity).\u003cbr\u003e\nPreferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed:29476152).\u003cbr\u003e\nBinds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed:9891060).\u003cbr\u003e\nBinding is isoform-specific. Binds to beta-actin\/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed:29476152).\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 212% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of IGF2BP2 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of IGF2BP2 expression in HEK293T (A), H1792 (B), K562 (C) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 66, 62 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: IMP2; VICKZ2; Insulin-like growth factor 2 mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IGF2BP2. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908728066227,"sku":"BS67251-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908728098995,"sku":"BS67251-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_04f5b88b-9fb4-4035-91e1-883e5e1396c3.jpg?v=1703006338","url":"https:\/\/afsbio.com\/products\/igf2bp2-polyclonal-antibody-bs67251","provider":"AFSBio Inc.","version":"1.0","type":"link"}