{"product_id":"igf2r-phospho-ser2484-polyclonal-antibody-bt-ap08854","title":"IGF2R (Phospho-Ser2484) Polyclonal Antibody - BT-AP08854","description":"\u003cp\u003eIGF2R (Phospho-Ser2484) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP08854-20, BT-AP08854-50, BT-AP08854-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions| including in the intracellular trafficking of lysosomal enzymes| the activation of transforming growth factor beta| and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however| imprinting of the human gene may be polymorphic| as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Immunology; Signal transduction; Tags and cell markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: IGF2R\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF, WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: IGF2R\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P11717\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: IGF2R;Phospho-Ser2484; Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P\/IGF2 receptor; M6P\/IGF2R; CD antigen CD222\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 3482\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238985851059,"sku":"BT-AP08854-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238985883827,"sku":"BT-AP08854-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238985916595,"sku":"BT-AP08854-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1920c295-2762-474c-bbb8-5a0552f9930a.png?v=1769387590","url":"https:\/\/afsbio.com\/products\/igf2r-phospho-ser2484-polyclonal-antibody-bt-ap08854","provider":"AFSBio Inc.","version":"1.0","type":"link"}