{"product_id":"ikzf1-monoclonal-antibody-bt-mca2024","title":"IKZF1 Monoclonal Antibody - BT-MCA2024","description":"\u003cp\u003eIKZF1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2024-50, BT-MCA2024-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction, Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: IKZF1\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4B6A12\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: IKZF1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human IKZF1 (AA: 401-520) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 57.5kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q13422\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: IK1, LYF1, LyF-1, CVID13, IKAROS, PPP1R92, PRO0758, ZNFN1A1, Hs.54452\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 10320\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238385967283,"sku":"BT-MCA2024-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238386000051,"sku":"BT-MCA2024-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d6d40512-ae7f-4a91-a690-e4a2691f66b1.png?v=1769379690","url":"https:\/\/afsbio.com\/products\/ikzf1-monoclonal-antibody-bt-mca2024","provider":"AFSBio Inc.","version":"1.0","type":"link"}