{"product_id":"il-10ralpha-polyclonal-antibody-bt-ap04431","title":"IL-10RAlpha Polyclonal Antibody - BT-AP04431","description":"\u003cp\u003eIL-10RAlpha Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP04431-20, BT-AP04431-50, BT-AP04431-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-10 receptor subunit alpha encoded by IL10RA is a receptor for interleukin 10. Interleukin-10 receptor subunit alpha is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2\/PI 3-kinase\/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: IL10RA\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: IL-10Ralpha Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 62904\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13651; Mouse: Q61727\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: IL10RA; IL10R; Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD antigen CD2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 3587\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240389468339,"sku":"BT-AP04431-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240389501107,"sku":"BT-AP04431-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240389533875,"sku":"BT-AP04431-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_a0d7b80f-b6d4-42a9-b456-2edbde7a812f.png?v=1769407763","url":"https:\/\/afsbio.com\/products\/il-10ralpha-polyclonal-antibody-bt-ap04431","provider":"AFSBio Inc.","version":"1.0","type":"link"}