{"product_id":"il-17ra-polyclonal-antibody-bs67226","title":"IL-17RA Polyclonal Antibody-BS67226","description":"\u003cp\u003eIL-17RA Polyclonal Antibody\u003c\/p\u003e \n\n\u003cp\u003eCatalogue Numbers: BS67226-50, BS67226-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q96F46\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539).\u003cbr\u003e\nReceptor for IL17F (PubMed:19838198, PubMed:17911633).\u003cbr\u003e\nBinds to IL17A with higher affinity than to IL17F (PubMed:17911633).\u003cbr\u003e\nBinds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495).\u003cbr\u003e\nAlso binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971).\u003cbr\u003e\nCytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122).\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 187% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of IL-17RA protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of IL-17RA expression in rat spleen (A), mouse lung (B), MCF7 (C) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 150-180 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: IL17R; Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; CDw217; CD217\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-17RA. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908725444787,"sku":"BS67226-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908725477555,"sku":"BS67226-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_84fe57ff-323c-4184-9e0e-49ec8b5d0815.jpg?v=1703006298","url":"https:\/\/afsbio.com\/products\/il-17ra-polyclonal-antibody-bs67226","provider":"AFSBio Inc.","version":"1.0","type":"link"}