{"product_id":"il-3rβ-rabbit-polyclonal-antibody-es2616","title":"IL-3Rβ Rabbit Polyclonal Antibody - ES2616","description":"\u003cp\u003eIL-3Rβ Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2616-50, ES2616-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CSF2RB, IL3RB, IL5RB, Cytokine receptor common subunit beta, CDw131, GM-CSF\/IL-3\/IL-5 receptor common beta subunit, CD antigen CD131\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human IL-3R beta. AA range:559-608\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: IL-3Rβ\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IL-3Rβ Polyclonal Antibody detects endogenous levels of IL-3Rβ protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Placenta,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 125kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Cytokine-cytokine receptor interaction, Apoptosis, JAK-STAT signaling pathway, Pathways in cancer\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM: 265120]. PAP is an autosomal recessive fatal respiratory disease\u003cbr\u003e\nDomain: The box 1 motif is required for JAK interaction and\/or activation\u003cbr\u003e\nDomain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding\u003cbr\u003e\nFunction: High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor\u003cbr\u003e\nSimilarity: Belongs to the type I cytokine receptor family. Type 4 subfamily\u003cbr\u003e\nSimilarity: Contains 2 fibronectin type-III domains\u003cbr\u003e\nSubunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Membrane, Single-pass type I membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CSF2RB\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Cytokine receptor common subunit beta\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 12983\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P26955\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314221699251,"sku":"ES2616-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314221732019,"sku":"ES2616-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/il-3r%ce%b2-rabbit-polyclonal-antibody-es2616","provider":"AFSBio Inc.","version":"1.0","type":"link"}