{"product_id":"il-4-rat-monoclonal-antibody-mb65863","title":"IL-4 Rat Monoclonal Antibody-MB65863","description":"\u003cp\u003eIL-4 Rat Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers:MB65863-50, MB65863-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rat IgG1 kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P07750\u003c\/p\u003e\n\n\u003cp\u003eHost: Rat\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IF (1\/50 - 1\/200)\u003c\/p\u003e\n\n\u003cp\u003eBackground: IL-4 is produced by T cells, NK T cells, γδ cells, and mast cells. Target cells include B cells, T cells, and macrophages. IL-4 induces the polarization of naïve helper T cells into the TH2 phenotype. IL-4 also promotes B cell proliferation, antibody class switching and the production other TH2 cytokines including IL-5 and IL-9. IL-4 induced TH2 polarization is important in developing humoral immunity against extracellular pathogens and is involved in the development of allergy and asthma. IL-4 binds to two distinct receptors, the Type I receptor and Type II receptor. Type I receptor is a heterodimer consisting of IL-4Rα chain and the common gamma chain, γc. Type II receptor, which is shared with IL-13, is a heterodimer of IL-4Rα and IL-13Rα1. Signaling initiated via Type I receptor results in the activation of Jak1\/Stat6, Jak3 and the PI3K\/Akt pathways. The Type II receptor activates the Jak1\/Stat6 and the Tyk2\/Stat3 pathways.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The monoclonal antibody  was affinity-purified from rat antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 15 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes mouse IL-4\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003cbr\u003e\nAlternative Name: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra\u003cbr\u003e\nConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42895058763955,"sku":"MB65863-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42895058796723,"sku":"MB65863-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_45366d2d-05b2-40ad-aa46-fc10727049f3.jpg?v=1702573142","url":"https:\/\/afsbio.com\/products\/il-4-rat-monoclonal-antibody-mb65863","provider":"AFSBio Inc.","version":"1.0","type":"link"}