{"product_id":"il-4r-cd124tyr497-polyclonal-antibody-ap0210","title":"IL-4R\/CD124(Tyr497) Polyclonal Antibody-AP0210","description":"\u003cp\u003eIL-4R\/CD124(Tyr497) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: AP0210-50, AP0210-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P24394\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:1000~1:2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: The IL-2 receptor is a multicomponent complex consisting of three subunits, α,β and γ, each of which is required for high affinity binding of IL-2. The α chainfunctions primarily in binding IL-2, whereas the β and γ chains contribute toIL-2 binding and are essential to IL-2-induced activation of signaling pathwaysleading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity ligand-binding cytokine receptors. However, it is nowwell established that the IL-2Rγ chain functions as a second subunit of thehigh affinity IL-4R and IL-7R receptors. Consequently, the originally describedsubunits of these latter receptors are now referred to as IL-4Rα and IL-7Rα,respectively, while the common subunit is referred to as γc. Although the common γ chain enhances ligand binding in these three cytokine receptors, ithas no capacity to bind these ligands on its own. There is evidence that theγc chain is also a subunit of IL-13R.\u003c\/p\u003e\n\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IL-4R\/CD124(Tyr497) polyclonal antibody detects endogenous levels of HIST1H3A protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of IL-4R\/CD124(Tyr497) polyclonal antibody at 1:2000 dilution\u003cbr\u003e\nLane1:HepG2 whole cell lysate(40ug)\u003cbr\u003e\nLane2:MCF-7 whole cell lysate(40ug)\u003cbr\u003e\nLane3:HCT116 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 85 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD_antigen: CD124; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; sIL4Ralpha\/prot; IL-4-binding protein; IL4-BP; IL4R; 582J2.1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human IL-4R\/CD124(Tyr497).\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908772565171,"sku":"AP0210-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908772597939,"sku":"AP0210-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_7c3934af-5a11-4504-9902-0acf04e84c38.jpg?v=1703006889","url":"https:\/\/afsbio.com\/products\/il-4r-cd124tyr497-polyclonal-antibody-ap0210","provider":"AFSBio Inc.","version":"1.0","type":"link"}