{"product_id":"il-4r-polyclonal-antibody-bs65584","title":"IL-4R Polyclonal Antibody-BS65584","description":"IL-4R Polyclonal Antibody\n\nSizes: 50µl, 100µl\n\nCatalogue Numbers: BS65584-50, BS65584-100\n\nProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\n\nSwiss-Prot: Q63257\n\nHost: Rabbit\n\nReactivity: Mouse, Rat, \n\nApplications: WB, \n\nAll Applications: WB=1:500-2000 \nnot yet tested in other applications.\noptimal dilutions\/concentrations should be determined by the end user.\n\nBackground: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].\n\nPurification and Purity: affinity purified by Protein A\n\nStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\n\nSpecificity: IL-4R polyclonal Antibody detects endogenous levels of IL-4R protein.\n\nBioworld Molecular Weight: ~140kDa\n\nNote: For research use only, not for use in diagnostic procedure.\n\nExtra Notes: Anti- IL-4R at 1\/1000 dilution, Anti- IL-4R at 1\/1000 dilution, Anti- IL-4R at 1\/1000 dilution\n\nAlternative Name: CD124; IL 4R alpha; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP; Il4r; IL4R nirs variant 1; IL4RA; IL4RA_HUMAN; Interleukin 4 receptor alpha chain; Interleukin 4 receptor; sIL4Ralpha\/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha. \n\nImmunogen: KLH conjugated synthetic peptide derived from rat IL-4R:111-210\/801 \u003cextracellular\u003e\n\nConjugate: Unconjugated\n\nModification: Unmodified\u003c\/extracellular\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42997567520947,"sku":"BS65584-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42997567553715,"sku":"BS65584-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_fbbc5805-859e-4bdd-a0dc-51b0e04d1700.jpg?v=1706270498","url":"https:\/\/afsbio.com\/products\/il-4r-polyclonal-antibody-bs65584","provider":"AFSBio Inc.","version":"1.0","type":"link"}