{"product_id":"il23a-rabbit-polyclonal-antibody-bt-ap10585","title":"IL23A Rabbit Polyclonal Antibody - BT-AP10585","description":"\u003cp\u003eIL23A Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10585-20, BT-AP10585-50, BT-AP10585-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: developmental stage:Expressed by newborns dendritic cells.|Associates with IL12B to form the IL-23 interleukin| an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R| activates the Jak-Stat signaling cascade| stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.|induction:Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues| in dendritic cells of multiple sclerosis patients and in tumors.|Belongs to the IL-6 superfamily.|subcellular location:Secreted upon association with IL12B.|subunit:Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.|tissue specificity:Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).|\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Immunology; Microbiology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: IL23A\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: IL23A\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 20790\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9NPF7\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: IL23A; Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238920741043,"sku":"BT-AP10585-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238920773811,"sku":"BT-AP10585-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238920806579,"sku":"BT-AP10585-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_cbf8e90a-3e63-48c2-bfbe-4540ea87ef00.png?v=1769386709","url":"https:\/\/afsbio.com\/products\/il23a-rabbit-polyclonal-antibody-bt-ap10585","provider":"AFSBio Inc.","version":"1.0","type":"link"}