{"product_id":"il6r-polyclonal-antibody-bs7203","title":"IL6R Polyclonal Antibody-BS7203","description":"\u003cp\u003eIL6R Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7203-50, BS7203-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P08887\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: IL-6 activates intracellular signaling through binding a receptor consisting of a ligand-binding protein (IL-6Rα) and a second protein. IL-6 first binds to IL-6Rα (also known as gp80), which subsequently associates with a gp130 dimer. The active signaling complex consists of, at minimum, IL-6, IL-6Rα and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6Rα, namely sIL-6Rα, is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-to-cell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes, including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IL6R polyclonal antibody detects endogenous levels of IL6R protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 52 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of IL6R polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane A: HEK293T whole cell lysate(40ug)\u003cbr\u003e\nLane B: Hela whole cell lysate(40ug)\u003cbr\u003e\nLane C: HGC27 whole cell lysate(40ug)\u003cbr\u003e\nLane D: The Liver tissue lysate of Mouse(40ug)\u003cbr\u003e\nLane E: The Lung tissue lysate of Mouse(40ug)\u003cbr\u003e\nLane F: The Liver tissue lysate of Rat(40ug)\u003cbr\u003e\nLane G: The Lung tissue lysate of Rat(40ug)\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD126; Soluble interleukin-6 receptor subunit alpha; Sil6r; IL6R\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human IL6R.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43021025411251,"sku":"BS7203-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43021025444019,"sku":"BS7203-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_1f4fdd44-8977-4038-8144-3f30052de610.jpg?v=1707050131","url":"https:\/\/afsbio.com\/products\/il6r-polyclonal-antibody-bs7203","provider":"AFSBio Inc.","version":"1.0","type":"link"}