{"product_id":"imp-cyclohydrolase-monoclonal-antibody-bt-mca0776","title":"IMP cyclohydrolase Monoclonal Antibody - BT-MCA0776","description":"\u003cp\u003eIMP cyclohydrolase Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA0776-50, BT-MCA0776-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Signal transduction; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ATIC\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Rabbit\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Bifunctional purine biosynthesis protein PURH\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P31939; Mouse: Q9CWJ9; Rat: O35567\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ATIC; PURH; OK; SW-cl.86; Bifunctional purine biosynthesis protein PURH\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 471\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238718628019,"sku":"BT-MCA0776-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238718660787,"sku":"BT-MCA0776-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_2980668e-33f7-4a4f-bf86-aaceca1a5f23.png?v=1769384074","url":"https:\/\/afsbio.com\/products\/imp-cyclohydrolase-monoclonal-antibody-bt-mca0776","provider":"AFSBio Inc.","version":"1.0","type":"link"}