{"product_id":"insulin-polyclonal-antibody-bt-ap10406","title":"Insulin Polyclonal Antibody - BT-AP10406","description":"\u003cp\u003eInsulin Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10406-20, BT-AP10406-50, BT-AP10406-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5andapos; region and with the IGF2 gene at the 3andapos; region. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction; Cardiovascular; Metabolism; Neuroscience; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: INS\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Insulin [Cleaved into: Insulin B chain; Insulin A chain]\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P01308\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Insulin [Cleaved into: Insulin B chain; Insulin A chain]; Insulin [Cleaved into: Insulin B chain; Insulin A chain;\u003c\/p\u003e \n\n\u003cp\u003eGeneID: Human: 3630; Mouse: 0\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239183409331,"sku":"BT-AP10406-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239183442099,"sku":"BT-AP10406-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239183474867,"sku":"BT-AP10406-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_4e7b4908-399d-4acd-9f92-0d731da77593.png?v=1769390240","url":"https:\/\/afsbio.com\/products\/insulin-polyclonal-antibody-bt-ap10406","provider":"AFSBio Inc.","version":"1.0","type":"link"}