{"product_id":"insulin-receptor-beta-phospho-tyr1345-rabbit-polyclonal-antibody-bt-ap03116","title":"Insulin Receptor beta (Phospho-Tyr1345) Rabbit Polyclonal Antibody - BT-AP03116","description":"\u003cp\u003eInsulin Receptor beta (Phospho-Tyr1345) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP03116-20, BT-AP03116-50, BT-AP03116-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway| which regulates glucose uptake and release| as well as the synthesis and storage of carbohydrates| lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome| Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cardiovascular; Metabolism; Neuroscience; Signal transduction; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: INSR\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Insulin Receptor beta\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P06213; Mouse: P15208; Rat: P15127\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Insulin Receptor β;Tyr1345; Insulin receptor; IR; EC 2.7.10.1; CD antigen CD220; Insulin receptor subunit alpha; Insulin receptor subunit beta;\u003c\/p\u003e \n\n\u003cp\u003eGeneID: Human: 3643; Mouse: 16337\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238999711923,"sku":"BT-AP03116-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238999744691,"sku":"BT-AP03116-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238999777459,"sku":"BT-AP03116-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_fb17a7de-b09f-48c9-8db4-e2bf077cab02.png?v=1769387766","url":"https:\/\/afsbio.com\/products\/insulin-receptor-beta-phospho-tyr1345-rabbit-polyclonal-antibody-bt-ap03116","provider":"AFSBio Inc.","version":"1.0","type":"link"}