{"product_id":"ints2-rabbit-polyclonal-antibody-es6911","title":"INTS2 Rabbit Polyclonal Antibody - ES6911","description":"\u003cp\u003eINTS2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6911-50, ES6911-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A, MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1, MIM 180680) and U2 (RNU2, MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: INTS2, KIAA1287, Integrator complex subunit 2, Int2\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human INTS2. AA range:201-250\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: INTS2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: INTS2 Polyclonal Antibody detects endogenous levels of INTS2 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Testis,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 140kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Caution: It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have shorter N-terminus\u003cbr\u003e\nFunction: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes\u003cbr\u003e\nPTM: Phosphorylated upon DNA damage, probably by ATM or ATR\u003cbr\u003e\nSimilarity: Belongs to the Integrator subunit 2 family\u003cbr\u003e\nSubunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9\/RC74, INTS10, CPSF3L\/INTS11 and INTS12\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Nucleus membrane, Single-pass membrane protein Cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: INTS2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Integrator complex subunit 2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 70422\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q80UK8\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313658613939,"sku":"ES6911-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313658646707,"sku":"ES6911-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/ints2-rabbit-polyclonal-antibody-es6911","provider":"AFSBio Inc.","version":"1.0","type":"link"}