{"product_id":"irf3-phospho-s386-polyclonal-antibody-bs94024","title":"IRF3 (Phospho-S386) Polyclonal Antibody-BS94024","description":"\u003cp\u003eIRF3 (Phospho-S386) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS94024-50, BS94024-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q14653(Human)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC\/IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000\u003cbr\u003e\nICC:1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-α and β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-α and interferon-β genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP).\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: ICC staining Phospho-IRF3 (S386) in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0. 25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 47 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IRF3 (Phospho-S386) polyclonal antibody detects endogenous levels of IRF3 protein only when phosphorylated at S386.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: IRF-3, IRF3, IIAE7, Interferon regulatory factor 3, IRF 3, IRF-3, IRF3, IRF3, MGC94729,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser386 of human IRF3.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939209842867,"sku":"BS94024-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939209875635,"sku":"BS94024-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_548dfc62-31bd-4135-85d1-9172d05e496f.jpg?v=1704545120","url":"https:\/\/afsbio.com\/products\/irf3-phospho-s386-polyclonal-antibody-bs94024","provider":"AFSBio Inc.","version":"1.0","type":"link"}