{"product_id":"irgm1-monoclonal-antibody-mb67131","title":"IRGM1 Monoclonal Antibody-MB67131","description":"\u003cp\u003eIRGM1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB67131-50, MB67131-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q60766\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Immunity-related GTPase family M protein 1 (IRGM, LRG-47) belongs to the p47 family of immunity related guanosine triphosphatases that regulate innate immune responses to intracellular pathogens. Research studies indicate that IRGM plays a role in autophagy during clearance of intracellular bacteria. Expression of IRGM in mice, but not in humans, is induced by inflammatory signals that include interferon and LPS. Polymorphisms in the corresponding IRGM gene are associated with some cases of tuberculosis, Crohn’s disease, and severe sepsis. Additional studies indicate that IRGM functions through regulation of autophagy. Mitochondrial IRGM plays a role in mitochondrial fission, membrane polarization, and mitophagy. Knockout mice for IRGM show increased susceptibility to infection as well as intestinal inflammation and Paneth cell abnormalities. Knockout mice against IRGM are also resistant to neuronal autophagy following stroke. RNA viruses commonly target IRGM in order to suppress autophagy and enhance infection.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was purified by immunogen affinity chromatography.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of IRGM1 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of IRGM1 expression in mouse brain (A), mouse heart (B) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 50 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: IFI1; IRGM1; LRG47; Immunity-related GTPase family M protein; Immunity-related GTPase family M protein 1; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG-47\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein corresponding to mouse IRGM1. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906410451123,"sku":"MB67131-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906410483891,"sku":"MB67131-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_7460b94c-14a7-4594-b947-c4f6af8d0794.jpg?v=1702919158","url":"https:\/\/afsbio.com\/products\/irgm1-monoclonal-antibody-mb67131","provider":"AFSBio Inc.","version":"1.0","type":"link"}