{"product_id":"itch-polyclonal-antibody-e-ab-91779","title":"ITCH Polyclonal Antibody - E-AB-91779","description":"\u003cp\u003eITCH Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-91779-60, E-AB-91779-120, E-AB-91779-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ITCH\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ITCH; ADMFD; AIF4; AIP4; NAPP1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q96J02\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human ITCH\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 103kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 100kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146619650227,"sku":"E-AB-91779-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146619682995,"sku":"E-AB-91779-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146619715763,"sku":"E-AB-91779-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_79a84fd9-e86b-4b17-a317-bf2eb6ab5ace.png?v=1710298595","url":"https:\/\/afsbio.com\/products\/itch-polyclonal-antibody-e-ab-91779","provider":"AFSBio Inc.","version":"1.0","type":"link"}