{"product_id":"itga6-polyclonal-antibody-e-ab-68362","title":"ITGA6 Polyclonal Antibody - E-AB-68362","description":"\u003cp\u003eITGA6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-68362-60, E-AB-68362-120, E-AB-68362-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ITGA6\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CD49f; ITGA6B; VLA-6; Integrin alpha 6; ITGA6\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Developmental Biology, Signal Transduction, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P23229\u003c\/p\u003e\n\n\u003cp\u003eBackground: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2\/HER2 signaling. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human ITGA6\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 106kDa\/119kDa\/121kDa\/122kDa\/124kDa\/126kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 125KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146489397427,"sku":"E-AB-68362-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146489430195,"sku":"E-AB-68362-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146489462963,"sku":"E-AB-68362-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_27f13222-adb9-44c5-880f-fba53fccb9e9.png?v=1710296358","url":"https:\/\/afsbio.com\/products\/itga6-polyclonal-antibody-e-ab-68362","provider":"AFSBio Inc.","version":"1.0","type":"link"}