{"product_id":"itm2b-polyclonal-antibody-e-ab-18661","title":"ITM2B Polyclonal Antibody - E-AB-18661","description":"\u003cp\u003eITM2B Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-18661-60, E-AB-18661-120, E-AB-18661-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ITM2B\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ABRI; ABri\/ADan amyloid peptide; BRI 2; BRI; BRI2; BRICD 2B; BRICD2B; BRICHOS domain containing 2B; E25B; E3 16; E3-16; FBD; imBRI2; Immature BRI2; Integral membrane protein 2B; ITM 2B; ITM2B; ITM2B; Protein E25B; RDGCA; Transmembrane protein BRI\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9Y287\u003c\/p\u003e\n\n\u003cp\u003eBackground: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.2 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human ITM2B\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 30 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43143894237363,"sku":"E-AB-18661-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43143894270131,"sku":"E-AB-18661-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43143894302899,"sku":"E-AB-18661-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c65bee7d-09cd-40c7-b5a7-ca168a16d63d.png?v=1710243235","url":"https:\/\/afsbio.com\/products\/itm2b-polyclonal-antibody-e-ab-18661","provider":"AFSBio Inc.","version":"1.0","type":"link"}