{"product_id":"itm2b-polyclonal-antibody-e-ab-90962","title":"ITM2B Polyclonal Antibody - E-AB-90962","description":"\u003cp\u003eITM2B Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-90962-60, E-AB-90962-120, E-AB-90962-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ITM2B\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ITM2B; ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; RDGCA; imBRI2\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9Y287\u003c\/p\u003e\n\n\u003cp\u003eBackground: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human ITM2B\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 18kDa\/30kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 30kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148765561011,"sku":"E-AB-90962-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148765593779,"sku":"E-AB-90962-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148765626547,"sku":"E-AB-90962-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_dafc53b0-8a02-47a3-ac1b-80b7b440a049.png?v=1710329544","url":"https:\/\/afsbio.com\/products\/itm2b-polyclonal-antibody-e-ab-90962","provider":"AFSBio Inc.","version":"1.0","type":"link"}