{"product_id":"itpr2-polyclonal-antibody-bs90745","title":"ITPR2 Polyclonal Antibody-BS90745","description":"\u003cp\u003eITPR2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90745-50, BS90745-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q14571(Human) Q9Z329(Mouse) P29995(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: DotBlot ICC IHC FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: DotBlot:1:2,000-1:5,000\u003cbr\u003e\nICC:1:50-1:100\u003cbr\u003e\nIHC:1:50-1:200\u003cbr\u003e\nFC:1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Protein affinity purified.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ITPR2 polyclonal antibody detects endogenous levels of ITPR2 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 308 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Dot blot analysis of anti-ITPR2 on PVDF. 0-4ug antigens were given in this test. Anti-ITPR2 antibody was diluted with 1\/500., ICC staining ITPR2 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: IP3R 2, InsP3R2, Type 2 InsP3 receptor, ITPR2, 4, 5-trisphosphate receptor, Inositol 1 4 5 trisphosphate receptor type 2, Inositol 1, 4, 5-trisphosphate receptor type 2, Inositol 145 trisphosphate receptor type 2, InsP3 R2, InsP3R2, IP3 R2, IP3 receptor, IP3 receptor isoform 2, IP3R 2, IP3R2, ITPR 2, Itpr2, ITPR2, Type 2 inositol 1 4 5 trisphosphate receptor, Type 2 inositol 1, Type 2 inositol 145 trisphosphate receptor, Type 2 InsP3 receptor,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant protein within human ITPR2 aa 1100-1450.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984583954611,"sku":"BS90745-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984583987379,"sku":"BS90745-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_bfacabdd-b8e8-4ceb-bd15-601d33b1d4fb.jpg?v=1705918726","url":"https:\/\/afsbio.com\/products\/itpr2-polyclonal-antibody-bs90745","provider":"AFSBio Inc.","version":"1.0","type":"link"}