{"product_id":"itpr2-polyclonal-antibody-e-ab-13345","title":"ITPR2 Polyclonal Antibody - E-AB-13345","description":"\u003cp\u003eITPR2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-13345-60, E-AB-13345-120, E-AB-13345-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ITPR2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 4; 5-trisphosphate receptor; Inositol 1 4 5 trisphosphate receptor type 2; Inositol 1; 4; 5-trisphosphate receptor type 2; Inositol 145 trisphosphate receptor type 2; InsP3 R2; InsP3R2; IP3 R2; IP3 receptor; IP3 receptor isoform 2; IP3R 2; IP3R2; ITPR 2; Itpr2; ITPR2; Type 2 inositol 1 4 5 trisphosphate receptor; Type 2 inositol 1; Type 2 inositol 145 trisphosphate receptor; Type 2 InsP3 receptor\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Metabolism, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q14571\u003c\/p\u003e\n\n\u003cp\u003eBackground: Inositol 1, 4, 5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4, 5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1, 4, 5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.9 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human ITPR2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"200μL","offer_id":43124128219315,"sku":"E-AB-13345-200","price":558.6,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43124128252083,"sku":"E-AB-13345-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"60μL","offer_id":43124128284851,"sku":"E-AB-13345-60","price":200.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_20e4ba80-0206-40cc-b1c7-e0098574cf1d.png?v=1709724314","url":"https:\/\/afsbio.com\/products\/itpr2-polyclonal-antibody-e-ab-13345","provider":"AFSBio Inc.","version":"1.0","type":"link"}