{"product_id":"itpr2-polyclonal-antibody-e-ab-52051","title":"ITPR2 Polyclonal Antibody - E-AB-52051","description":"\u003cp\u003eITPR2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-52051-60, E-AB-52051-120, E-AB-52051-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ITPR2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 4; 5-trisphosphate receptor; Inositol 1 4 5 trisphosphate receptor type 2; Inositol 1; 4; 5-trisphosphate receptor type 2; Inositol 145 trisphosphate receptor type 2; InsP3 R2; InsP3R2; IP3 R2; IP3 receptor; IP3 receptor isoform 2; IP3R 2; IP3R2; ITPR 2; Itpr2; ITPR2; Type 2 inositol 1 4 5 trisphosphate receptor; Type 2 inositol 1; Type 2 inositol 145 trisphosphate receptor; Type 2 InsP3 receptor\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Metabolism, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q14571\u003c\/p\u003e\n\n\u003cp\u003eBackground: Inositol 1, 4, 5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4, 5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1, 4, 5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.74 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human ITPR2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:300, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133443506355,"sku":"E-AB-52051-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133443539123,"sku":"E-AB-52051-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133443571891,"sku":"E-AB-52051-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_704afc9c-07ba-431d-9dfe-aeb8a77b5d2c.png?v=1709899093","url":"https:\/\/afsbio.com\/products\/itpr2-polyclonal-antibody-e-ab-52051","provider":"AFSBio Inc.","version":"1.0","type":"link"}