{"product_id":"jagged1-polyclonal-antibody-bs90747","title":"Jagged1 Polyclonal Antibody-BS90747","description":"\u003cp\u003eJagged1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90747-50, BS90747-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P78504(Human) Q9QXX0(Mouse) Q63722(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000\u003cbr\u003e\nIHC:1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: The LIN-12\/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged is a membrane protein and can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Jagged is expressed in adult and fetal tissues, and expression is upregulated in cervical squamous cell carcinoma. Familial Tetralogy of Fallot, the most common form of complex congenital heart disease, is caused by a mutation in the Jagged1 gene.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Jagged1 polyclonal antibody detects endogenous levels of Jagged1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 134 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Jagged1 antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Jagged1 antibody. Counter stained with hematoxylin.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Jagged1, hJ1, JAG1, AGS, AHD, AWS, CD 339, CD339, CD339 antigen, Headturner, hJ1, Htu, Jag 1, Jag1, JAG1, Jagged 1, Jagged1 (Alagille syndrome), Jagged1, JAGL1, MGC104644, OTTHUMP00000030278, Protein jagged-1, Ser 1, Ser1, Serrate 1, Slalom,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984584151219,"sku":"BS90747-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984584183987,"sku":"BS90747-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_f9d9273c-a6d3-444c-81b0-c33c9da10487.jpg?v=1705918731","url":"https:\/\/afsbio.com\/products\/jagged1-polyclonal-antibody-bs90747","provider":"AFSBio Inc.","version":"1.0","type":"link"}