{"product_id":"jak1-phospho-tyr1034-1035-rabbit-polyclonal-antibody-es15397","title":"Jak1 (phospho-Tyr1034\/1035) Rabbit Polyclonal Antibody - ES15397","description":"\u003cp\u003eJak1 (phospho-Tyr1034\/1035) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES15397-50, ES15397-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha\/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized phosho peptide around human Jak1(Tyr1034 and 1035)\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: JAK1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of Human Mouse Rat Jak1(phospho-Tyr1034 or 1035)\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed at higher levels in primary colon tumors than in normal colon tissue, The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 132kD\u003c\/p\u003e\n\n\u003cp\u003eFields: EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Leishmaniasis, Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer, Viral carcinogenesis, Pancreatic cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate\u003cbr\u003e\nDomain: Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1\u003cbr\u003e\nDomain: The FERM domain mediates interaction with JAKMIP1\u003cbr\u003e\nFunction: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha\/beta\/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor\u003cbr\u003e\nSequence Caution: Translation N-terminally extended\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily\u003cbr\u003e\nSimilarity: Contains 1 FERM domain\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nSimilarity: Contains 1 SH2 domain\u003cbr\u003e\nSubcellular Location: Wholly intracellular, possibly membrane associated\u003cbr\u003e\nSubunit: Interacts with IL31RA, JAKMIP1 and SHB\u003cbr\u003e\ntissue specif\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Endomembrane system, Peripheral membrane protein Wholly intracellular, possibly membrane associated\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: JAK1 JAK1A JAK1B\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Jak1(Tyr1034\/1035)\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P52332\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315289018547,"sku":"ES15397-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315289051315,"sku":"ES15397-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/jak1-phospho-tyr1034-1035-rabbit-polyclonal-antibody-es15397","provider":"AFSBio Inc.","version":"1.0","type":"link"}