{"product_id":"jak2-phospho-y570-polyclonal-antibody-bs4610","title":"JAK2 (phospho-Y570) Polyclonal Antibody - BS4610","description":"\u003cp\u003eJAK2 (phospho-Y570) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4610-50, BS4610-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regμlate a spectrum of cellμlar functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimμli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regμlate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimμlating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: JAK 2, JAK-2, JAK2, Janus Activating Kinase 2, Janus Kinase 2, Janus Kinase 2, JTK 10, JTK10,\u003c\/p\u003e \n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyrosine 570.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-JAK2 (Y570) polyclonal antibody detects endogenous levels of JAK2 only when phosphorylated at Tyr570.\u003c\/p\u003e \n\n\u003cp\u003eMolecular Weight: ~ 125 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Jak Stat: IL-6 Receptor Signaling, Inhibition of Apoptosis,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: O60674\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946305216691,"sku":"BS4610-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946305249459,"sku":"BS4610-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/jak2-phospho-y570-polyclonal-antibody-bs4610","provider":"AFSBio Inc.","version":"1.0","type":"link"}