{"product_id":"jdp2-phospho-thr148-rabbit-pab-es4704","title":"JDP2 (phospho Thr148) rabbit pAb - ES4704","description":"\u003cp\u003eJDP2 (phospho Thr148) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4704-50, ES4704-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: function:Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3\/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin., PTM:Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments., similarity:Belongs to the bZIP family. ATF subfamily., similarity:Contains 1 bZIP domain., subunit:Forms homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA response element (TRE) either as homodimer or heterodimer.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: JDP2; Jun dimerization protein 2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human JDP-2 around the phosphorylation site of Thr148. AA range:114-163\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 122953\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q8WYK2\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201807442099,"sku":"ES4704-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201807474867,"sku":"ES4704-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_49b8ab1c-f79f-46e5-9603-bcda2c57fdfe.png?v=1767112273","url":"https:\/\/afsbio.com\/products\/jdp2-phospho-thr148-rabbit-pab-es4704","provider":"AFSBio Inc.","version":"1.0","type":"link"}