{"product_id":"jik-rabbit-pab-es2658","title":"JIK rabbit pAb - ES2658","description":"\u003cp\u003eJIK rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2658-50, ES2658-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1\/ERK2 and JNK\/SAPK., PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily. STE Ser\/Thr protein kinase family. STE20 subfamily., similarity:Contains 1 protein kinase domain., subcellular location:Also localized to the peripheral cell membrane., subunit:Self-associates., tissue specificity:Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: TAOK3; DPK; JIK; KDS; MAP3K18; Serine\/threonine-protein kinase TAO3; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; JNK\/SAPK-inhibitory kinase; Jun kinase-inhi\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA; IHC\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human TAOK3. AA range:531-580\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 110kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 51347\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q9H2K8\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein. Also localized to the peripheral cell membrane.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202090295475,"sku":"ES2658-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202090328243,"sku":"ES2658-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_66b0f800-9d59-4f35-bab5-3c5b0ffc94d0.png?v=1767121641","url":"https:\/\/afsbio.com\/products\/jik-rabbit-pab-es2658","provider":"AFSBio Inc.","version":"1.0","type":"link"}