{"product_id":"jnk1-2-3-phospho-t183-y185-polyclonal-antibody-bs4322","title":"JNK1\/2\/3 (phospho-T183\/Y185) Polyclonal Antibody - BS4322","description":"\u003cp\u003eJNK1\/2\/3 (phospho-T183\/Y185) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4322-50, BS4322-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregμlate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regμlation. JNK3 is crucial for neuronal apoptosis (stress-induced).\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: JNK 46, JNK 55, JNK, JNK1, JNK1A2, JNK2, JNK21B1\/2, JNK2ALPHA, JNK2B, JNK2BETA, JNK3, JNK3A, MAP kinase 8, MAP kinase 9, MAP kinase p49 3F12, MAPK 8, MAPK 9, MAPK10, MAPK8, MAPK9, MGC50974, Mitogen activated protein kinase 10, Mitogen activated protein kinase 8, Mitogen activated protein kinase 9\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human JNK1 around the phosphorylation site of Threonine 183 and Tyrosine 185.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-JNK1\/2\/3 (T183\/Y185) polyclonal antibody detects endogenous levels of JNK1\/2\/3 protein only when phosphorylated at Thr183 and Tyr185.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 46, 54 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Immune Cell Signaling, SAPK JNK Signaling Cascades, Inhibition of Apoptosis, G Protein-coupled Receptors Signaling to MAPK Erk, MAPK Erk in Growth and Differentiation Pathway, MAPK Erk in Growth and Differentiation Pathway, Mitochondrial Control of Apoptosis, ErbB HER Signaling, ErbB HER Signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P45983\/P45984\/P53779\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946299580595,"sku":"BS4322-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946299613363,"sku":"BS4322-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/jnk1-2-3-phospho-t183-y185-polyclonal-antibody-bs4322","provider":"AFSBio Inc.","version":"1.0","type":"link"}