{"product_id":"jnk1-2-3-polyclonal-antibody-e-ab-93242","title":"JNK1\/2\/3 Polyclonal Antibody - E-AB-93242","description":"\u003cp\u003eJNK1\/2\/3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-93242-60, E-AB-93242-120, E-AB-93242-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: JNK1\/2\/3\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, IF, IP\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P45983\/P45984\/P53779\u003c\/p\u003e\n\n\u003cp\u003eBackground: JNK belongs to MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1, JNK2, and JNK3\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human JNK1\/2\/3\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:200, IP 1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 35kDa\/44kDa\/48kDa\/27kDa\/52kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 46kDa\/54kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43145989423283,"sku":"E-AB-93242-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43145989456051,"sku":"E-AB-93242-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43145989488819,"sku":"E-AB-93242-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_104556b6-0697-4fbd-8993-23af440b052d.png?v=1710289370","url":"https:\/\/afsbio.com\/products\/jnk1-2-3-polyclonal-antibody-e-ab-93242","provider":"AFSBio Inc.","version":"1.0","type":"link"}