{"product_id":"jnk1-jnk2-jnk3-polyclonal-antibody-bs65605","title":"JNK1+JNK2+JNK3 Polyclonal Antibody-BS65605","description":"\u003cp\u003eJNK1+JNK2+JNK3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65605-50, BS65605-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q61831\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, (predicted: Dog, Pig, Cow, )\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-P\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB=1:500-2000  IHC-P=1:100-500\u003c\/p\u003e\n\n\u003cp\u003eBackground: JNK1(MAPK8) is a member of the MAP kinase family. JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7.\u003cbr\u003e\nJNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53.\u003cbr\u003e\nJNK3 is a neuron-specific form of c-Jun N-terminal kinases. Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis.\u003cbr\u003e\nThe JNK pathway is critically involved in diabetes and levels are abnormally elevated in obesity.\u003c\/p\u003e\n\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: JNK1+JNK2+JNK3 Polyclonal Antibody detects endogenous levels of JNK1+JNK2+JNK3 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 42-52 kD\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Sample:\u003cbr\u003e\n Kidney (Mouse) Lysate at 40 ug\u003cbr\u003e\n Primary: Anti-JNK1+JNK2+JNK3 at 1\/300 dilution, Sample:\u003cbr\u003e\n Cerebrum(Rat) Lysate at 40 ug\u003cbr\u003e\n Cerebrum(Mouse) Lysate at 40 ug\u003cbr\u003e\n Heart(Rat) Lysate at 40 ug\u003cbr\u003e\n Heart(Mouse) Lysate at 40 ug\u003cbr\u003e\n Cerebellum(Rat) Lysate at 40 ug\u003cbr\u003e\n Cerebellum(Mouse) Lysate at 40 ug\u003cbr\u003e\n Primary: Anti-JNK1+JNK2+JNK3 at 1\/1000 dilution, Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (JNK1+JNK2+JNK3) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C,\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: JNK1 + JNK2 + JNK3; JNK1\/2\/3; JNK1+2+3; JNK1 + JNK2 + JNK3; MAPK10; c Jun N terminal kinase 1; c Jun N terminal kinase 2; c Jun N terminal kinase 3; JNK; JNK1; JNK2; JNK2ALPHA; JNK2BETA; JNK3; MAPK8; MAPK9; Mitogen activated protein kinase 10; Mitogen activated protein kinase 8; Mitogen activated protein kinase 9; SAPK(beta); Stress activated protein kinase JNK1; Stress activated protein kinase JNK2; Stress activated protein kinase JNK3; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA.\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: KLH conjugated synthetic peptide derived from human JNK1\/2\/3:151-250\/384\u003c\/p\u003e \n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42997567815859,"sku":"BS65605-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42997567848627,"sku":"BS65605-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_6aed0a70-8e9b-41e0-b3e1-a837c0a414ec.jpg?v=1706270502","url":"https:\/\/afsbio.com\/products\/jnk1-jnk2-jnk3-polyclonal-antibody-bs65605","provider":"AFSBio Inc.","version":"1.0","type":"link"}