{"product_id":"k-ras-rabbit-pab-es8441","title":"K-Ras rabbit pAb - ES8441","description":"\u003cp\u003eK-Ras rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8441-50, ES8441-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: GTPase KRas (K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC-p: 100-300.Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human KRAS. AA range:150-189\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 22kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 3845\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P01116\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Endomembrane system. Cytoplasm, cytosol.; [Isoform 2B]: Cell membrane; Lipid-anchor.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202380128435,"sku":"ES8441-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202380161203,"sku":"ES8441-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_21ab2d82-25f6-41d8-bec3-5d81cab4eeaa.png?v=1767127897","url":"https:\/\/afsbio.com\/products\/k-ras-rabbit-pab-es8441","provider":"AFSBio Inc.","version":"1.0","type":"link"}