{"product_id":"kal1-polyclonal-antibody-bs5771","title":"KAL1 Polyclonal Antibody-BS5771","description":"\u003cp\u003eKAL1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS5771-50, BS5771-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Anosmin1; Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein; KAL1; ADMLX; KAL; KALIG1\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P23352\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Kallmann (KAL1) syndrome is an X-linked condition characterized by hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency, and a defective sense of smell, known as anosmia, due to the underdevelopment of the olfactory bulbs. GnRH is a key regulator of reproduction and sexual behavior. Anosmia associated with Kallmann syndrome is due to a defect in the migration and targeting of GnRH-secreting neurons and olfactory axons during embryonic development. Mutations in the KAL1 gene are responsible for X-linked Kallmann syndrome. The human KAL1 gene, located in the Xp22.3 region, encodes a 680 amino acid extracellular matrix adhesion protein, known as anosmin-1. Anosmin-1 plays an essential role in the patterning of mitral and tufted cell axon collaterals to the olfactory cortex. Anosmin-1 can be detected in the basement membranes and\/or interstitial matrices of various structures including bronchial tubes, muscular walls of the digestive tract and forebrain subregions.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: KAL1 polyclonal antibody detects endogenous levels of KAL1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 76 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of KAL1 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: Jurkat cell lysate\u003cbr\u003e\nLane 2: Mouse heart tissue lysate\u003cbr\u003e\nLane 3: Rat heart tissue lysate\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 205-250 of Human KAL1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42911815991475,"sku":"BS5771-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42911816024243,"sku":"BS5771-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_a6f44be5-4fc1-460d-b09c-853694bb3d1a.jpg?v=1703179889","url":"https:\/\/afsbio.com\/products\/kal1-polyclonal-antibody-bs5771","provider":"AFSBio Inc.","version":"1.0","type":"link"}