{"product_id":"kbtba-rabbit-polyclonal-antibody-es15353","title":"KBTBA Rabbit Polyclonal Antibody - ES15353","description":"\u003cp\u003eKBTBA Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES15353-50, ES15353-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB\/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human KBTBA AA range: 268-318\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: KBTBA\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of KBTBA at Human\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Sarcomeric muscle,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 67kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins\u003cbr\u003e\nPathway: Protein modification, protein ubiquitination\u003cbr\u003e\nPTM: Ubiquitinated and probably targeted for proteasome-independent degradation\u003cbr\u003e\nSimilarity: Contains 1 BTB (POZ) domain\u003cbr\u003e\nSimilarity: Contains 5 Kelch repeats\u003cbr\u003e\nSubcellular Location: Predominantly cytoplasmic but can co-localize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia\u003cbr\u003e\nSubunit: Interacts with NRAP (By similarity). Part of a complex that contains CUL3, RBX1 and KBTBD10\u003cbr\u003e\nTissue Specificity: Sarcomeric muscle\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm Cytoplasm, cytoskeleton Cell projection, pseudopodium Cell projection, ruffle Cytoplasm, myofibril, sarcomere, M line Sarcoplasmic reticulum membrane Endoplasmic reticulum membrane Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: KBTBD10 KRP1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: KBTBA\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 117537\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q9ER30\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315264377011,"sku":"ES15353-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315264409779,"sku":"ES15353-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/kbtba-rabbit-polyclonal-antibody-es15353","provider":"AFSBio Inc.","version":"1.0","type":"link"}