{"product_id":"kcnq2-polyclonal-antibody-e-ab-92142","title":"KCNQ2 Polyclonal Antibody - E-AB-92142","description":"\u003cp\u003eKCNQ2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92142-60, E-AB-92142-120, E-AB-92142-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: KCNQ2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: KCNQ2; BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KV7.2\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O43526\u003c\/p\u003e\n\n\u003cp\u003eBackground: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human KCNQ2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 44kDa\/92kDa\/93kDa\/94kDa\/95kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 95KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148834865331,"sku":"E-AB-92142-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148834898099,"sku":"E-AB-92142-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148834930867,"sku":"E-AB-92142-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_508cf7a8-5cc1-4fbb-bb27-e527eca00a5b.png?v=1710330996","url":"https:\/\/afsbio.com\/products\/kcnq2-polyclonal-antibody-e-ab-92142","provider":"AFSBio Inc.","version":"1.0","type":"link"}