{"product_id":"kd-validatedfgfr3-rabbit-pab-a24846","title":"[KD Validated]FGFR3 Rabbit pAb - A24846","description":"\u003cp\u003e[KD Validated]FGFR3 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A24846-20, A24846-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 75kDa\/85kDa\/87kDa\/88kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 100-150kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment) .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2261\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P22607\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: FGFR3; ACH; CD333; CEK2; HSFGFR3EX; JTK4; fibroblast growth factor receptor 3\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal Transduction, Kinase, Tyrosine kinases, Cell Biology \u0026amp; Developmental Biology, Growth factor, ESC Pluripotency and Differentiation, Immunology \u0026amp; Inflammation, CD markers, Stem Cells, Neural Stem Cells, Cardiovascular, Angiogenesis.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: FGFR3\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189858230451,"sku":"A24846-20","price":179.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189858263219,"sku":"A24846-100","price":515.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_fddb8687-7d35-49f5-9585-72926db6e31d.png?v=1766436904","url":"https:\/\/afsbio.com\/products\/kd-validatedfgfr3-rabbit-pab-a24846","provider":"AFSBio Inc.","version":"1.0","type":"link"}