{"product_id":"kdm1a-monoclonal-antibody-mb11143","title":"KDM1A Monoclonal Antibody-MB11143","description":"\u003cp\u003eKDM1A Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB11143-50, MB11143-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O60341\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Hamster, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC\/IF, IP,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000  IF: 1\/50-1\/200  IP: 1\/20\u003c\/p\u003e  \n\n\u003cp\u003eBackground: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 93 kDa; Observed MW: 110 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of KDM1\/LSD1 in Jurkat lysates using KDM1A antibody., Western blot analysis of KDM1\/LSD1 in Hela, CHO-K1, C6, Jurkat lysates using KDM1\/LSD1 antibody., Immunocytochemistry analysis of KDM1\/LSD1 in Hela using KDM1\/LSD1 antibody, and DAPI\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human KDM1\/LSD1\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43004738896051,"sku":"MB11143-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43004738928819,"sku":"MB11143-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_20034e39-f3ca-40bf-a8e3-c119ca5d06f1.jpg?v=1706445145","url":"https:\/\/afsbio.com\/products\/kdm1a-monoclonal-antibody-mb11143","provider":"AFSBio Inc.","version":"1.0","type":"link"}