{"product_id":"kdm5a-polyclonal-antibody-bs90765","title":"KDM5A Polyclonal Antibody-BS90765","description":"\u003cp\u003eKDM5A Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90765-50, BS90765-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P29375(Human)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC IF FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500\u003cbr\u003e\nICC:1:50-1:400\u003cbr\u003e\nFC:1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL\/BMAL1-mediated transcriptional activation of PER1\/2 and other clock-controlled genes and increases histone acetylation at PER1\/2 promoters by inhibiting the activity of HDAC1. Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: KDM5A polyclonal antibody detects endogenous levels of KDM5A protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 192 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of KDM5A on A549 cell using anti-KDM5A antibody at 1\/500 dilution., ICC staining KDM5A in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: RBBP-2, KDM5A, JARID1A, RBBP2, RBP2, Histone demethylase JARID1A, JARID1A, Jumonji\/ARID domain containing protein 1A, Jumonji\/ARID domain-containing protein 1A, Kdm5a, KDM5A, Lysine-specific demethylase 5A, RBBP-2, RBBP2, RBP2, Retinoblastoma binding protein 2, Retinoblastoma-binding protein 2 antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984585494707,"sku":"BS90765-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984585527475,"sku":"BS90765-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e29a4822-ddec-4694-a4c3-a5d14e38eeb2.jpg?v=1705918760","url":"https:\/\/afsbio.com\/products\/kdm5a-polyclonal-antibody-bs90765","provider":"AFSBio Inc.","version":"1.0","type":"link"}