{"product_id":"ki67-monoclonal-antibody-e-ab-22027","title":"KI67 Monoclonal Antibody - E-AB-22027","description":"\u003cp\u003eKI67 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-22027-60, E-AB-22027-120, E-AB-22027-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Ki 67\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Antigen identified by monoclonal Ki 67; Antigen identified by monoclonal Ki-67; Antigen KI-67; Antigen KI67; Antigen Ki67; KI67; KIA; Marker of proliferation Ki-67; MIB 1; MIB; MKI67; PPP1R105; Proliferation marker protein Ki-67; Proliferation related Ki 67 antigen; Protein phosphatase 1 regulatory subunit 105; RP11-380J17.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Neuroscience, Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC-p, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone No.: Clone:8K5\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P46013\u003c\/p\u003e\n\n\u003cp\u003eBackground: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Protein A purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:100-1:300, IF 1:50-200\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43135918604467,"sku":"E-AB-22027-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43135918637235,"sku":"E-AB-22027-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43135918670003,"sku":"E-AB-22027-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_4fc937f7-ff94-461d-bb2e-2588810ef25f.png?v=1709986496","url":"https:\/\/afsbio.com\/products\/ki67-monoclonal-antibody-e-ab-22027","provider":"AFSBio Inc.","version":"1.0","type":"link"}