{"product_id":"kif1b-rabbit-polyclonal-antibody-es15308","title":"KIF1B Rabbit Polyclonal Antibody - ES15308","description":"\u003cp\u003eKIF1B Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES15308-50, ES15308-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human KIF1B AA range: 1331-1381\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: KIF1B\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of KIF1B at Human\/Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Isoform 3 is abundant in the skeletal muscle, It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine, Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 200kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in KIF1B are the cause of Charcot-Marie-Tooth disease type 2A1 (CMT2A1) [MIM: 118210]. CMT2A1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy\u003cbr\u003e\nFunction: Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility\u003cbr\u003e\nSimilarity: Belongs to the kinesin-like protein family\u003cbr\u003e\nSimilarity: Belongs to the kinesin-like protein family. U\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm, cytoskeleton Mitochondrion Cell projection, axon, [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: KIF1B KIAA0591 KIAA1448\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: KIF1B\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 16561\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q60575\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 117548\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: O88658\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315242782899,"sku":"ES15308-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315242815667,"sku":"ES15308-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/kif1b-rabbit-polyclonal-antibody-es15308","provider":"AFSBio Inc.","version":"1.0","type":"link"}