{"product_id":"kir2ds4-polyclonal-antibody-bs7683","title":"KIR2DS4 Polyclonal Antibody-BS7683","description":"\u003cp\u003eKIR2DS4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7683-50, BS7683-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P43632\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB\t1:500 - 1:2000\u003cbr\u003e\nIF\t1:50 - 1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several \"framework\" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: KIR2DS4 polyclonal antibody detects endogenous levels of KIR2DS4 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 34 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot analysis of extract of various cells, using KIR2DS4 antibody.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CD158 antigen like family member I; \u003cbr\u003e\nCD158 antigen-like family member I; \u003cbr\u003e\nCD158i; \u003cbr\u003e\nCD158i antigen; \u003cbr\u003e\nCL 17; \u003cbr\u003e\nCL 39; \u003cbr\u003e\nCL17; \u003cbr\u003e\nCL39; \u003cbr\u003e\nKI2S4_HUMAN; \u003cbr\u003e\nKiller cell immunoglobulin like receptor two domains short cytoplasmic tail 4; \u003cbr\u003e\nKiller cell immunoglobulin-like receptor 2DS4; \u003cbr\u003e\nKiller inhibitory receptor 4 1 2; \u003cbr\u003e\nKIR antigen 2DS4; \u003cbr\u003e\nKIR1D; \u003cbr\u003e\nKIR2DS4; \u003cbr\u003e\nKIR412; \u003cbr\u003e\nKKA3; \u003cbr\u003e\nMGC120019; \u003cbr\u003e\nMGC125315; \u003cbr\u003e\nMGC125317; \u003cbr\u003e\nMHC class I NK cell receptor; \u003cbr\u003e\nNatural killer associated transcript 8; \u003cbr\u003e\nNatural killer cell inhibitory receptor; \u003cbr\u003e\nNatural killer-associated transcript 8; \u003cbr\u003e\nNKAT 8; \u003cbr\u003e\nNKAT-8; \u003cbr\u003e\nNKAT8; \u003cbr\u003e\nOTTHUMP00000199030; \u003cbr\u003e\nP58 natural killer cell receptor clone CL 39; \u003cbr\u003e\nP58 natural killer cell receptor clones CL-39\/CL-17; \u003cbr\u003e\np58 NK receptor; \u003cbr\u003e\np58 NK receptor CL-39\/CL-17;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant full length Human KIR2DS4.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923511677107,"sku":"BS7683-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923511709875,"sku":"BS7683-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_1ec7cede-4b94-4bbb-a156-0d348abf48fe.jpg?v=1703850810","url":"https:\/\/afsbio.com\/products\/kir2ds4-polyclonal-antibody-bs7683","provider":"AFSBio Inc.","version":"1.0","type":"link"}