{"product_id":"kir3-1-phospho-ser185-polyclonal-antibody-ra26659","title":"KIR3.1 (phospho Ser185) Polyclonal Antibody - RA26659","description":"KIR3.1 (phospho Ser185) Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA26659-50, RA26659-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: potassium voltage-gated channel subfamily J member 3 (KCNJ3) Homo sapiens Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, at\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\n\nAlternative Names: KCNJ3; GIRK1; G protein-activated inward rectifier potassium channel 1; GIRK-1; Inward rectifier K (+) channel Kir3.1; Potassium channel; inwardly rectifying subfamily J member 3\n\nApplications: WB; IHC-p; IF\/ICC; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat; Monkey\n\nGeneID (Human): 3760\n\nProtein MW (KDa): 50\n\nSWISS: P48549\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121371177139,"sku":"RA26659-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121371209907,"sku":"RA26659-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_88d418b5-9b62-4c93-946f-46b32aca1ee5.png?v=1773346900","url":"https:\/\/afsbio.com\/products\/kir3-1-phospho-ser185-polyclonal-antibody-ra26659","provider":"AFSBio Inc.","version":"1.0","type":"link"}